Transplantation of Adult Mouse iPS Cell-Derived Photoreceptor Precursors Restores Retinal Structure and Function in Degenerative Mice

Correction: Transplantation of Adult Mouse iPS Cell-Derived Photoreceptor Precursors Restores Retinal Structure and Function in Degenerative Mice

The affiliation for the seventh author is incorrect. Stephen Redenti is not affiliated with #1 but with #2 Department of Ophthalmology, Schepens Eye Research Institute, Harvard Medical School, Boston, Massachusetts, United States of America. Dr. Redenti’s current address is: Biochemistry Doctoral Program, The Graduate School and University Center, City University of New York, Department of Biol...

Morphological changes in injured retinal pigment epithelium and photoreceptor cells after transplantation of stem cells into subretinal space

Introduction: Degenerative retinal diseases are main cause of irreversible blindness. Stem cells therapy is a promising way in these diseases. Therefore, mesenchymal stem cells because of its safety can produce degenerated cells and can play important role in treatment. The aim of this study was to examine morphological changes in injured retinal pigment epithelium (RPE) and photoreceptor cells...

Photoreceptor precursors derived from three-dimensional embryonic stem cell cultures integrate and mature within adult degenerate retina

Irreversible blindness caused by loss of photoreceptors may be amenable to cell therapy. We previously demonstrated retinal repair and restoration of vision through transplantation of photoreceptor precursors obtained from postnatal retinas into visually impaired adult mice. Considerable progress has been made in differentiating embryonic stem cells (ESCs) in vitro toward photoreceptor lineages...

Comparison of Neonatal and Adult Mice-derived Sertoli Cells in Support of Expansion of Mouse Spermatogonial Stem Cells In vitro

Transplantation of human embryonic stem cell-derived photoreceptors restores some visual function in Crx-deficient mice.

Some of the most common causes of blindness involve the degeneration of photoreceptors in the neural retina; photoreceptor replacement therapy might restore some vision in these individuals. Embryonic stem cells (ESCs) could, in principle, provide a source of photoreceptors to repair the retina. We have previously shown that retinal progenitors can be efficiently derived from human ESCs. We now...